Prevalence of Endometriosis in Women Presenting with Infertility: Hospital-based Cross-sectional Study

Prevalence of Endometriosis in Women Presenting with Infertility

Authors

  • Bushra Gull Department of Obstetrics and Gynaecology, Combined Military Hospital, Multan, Pakistan
  • Lubna Noor Department of Obstetrics and Gynaecology, Combined Military Hospital, Multan, Pakistan
  • Sadia Majeed Department of Obstetrics and Gynaecology, Combined Military Hospital, Multan, Pakistan
  • Sadaf Mumtaz Department of Obstetrics and Gynaecology, Combined Military Hospital, Multan, Pakistan
  • Nadia Naheed Department of Obstetrics and Gynaecology, Combined Military Hospital, Multan, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v7i10.4023

Keywords:

Endometriosis, Infertility, Laparoscopy, Obesity, Pain

Abstract

Endometriosis is a gynaecologic disorder that can impair fertility, yet it’s prevalence among women presenting with infertility remains variably reported across clinical settings. Objectives: To determine prevalence of endometriosis in women presenting with infertility. Methods: This descriptive cross-sectional study was performed at the Department of Obstetrics and Gynecology, Combined Military Hospital Multan. Ninety-five married women aged 20-40 years presenting with infertility were enrolled through non-probability consecutive sampling. Baseline sociodemographic, menstrual, and clinical characteristics were recorded. Hormonal evaluation included thyroid-stimulating hormone, luteinizing hormone, follicle-stimulating hormone, and prolactin. All participants underwent diagnostic laparoscopy under general anesthesia by experienced consultants. Endometriosis was diagnosed based on characteristic peritoneal lesions visualized on laparoscopy. Data were analyzed utilizing SPSS version 27. Comparative analyses were performed utilizing an independent sample t-test and chi-square test. Results: Mean age was 29.9 ± 4.8 years. Primary infertility was present in 69 (72.6%) and obesity in 47 (49.5%). In 30 (31.6%) of cases women were illiterate, and 58 (61.1%) were from the lower middle socioeconomic class. Endometriosis was identified in 16 (16.8%) of the participants. Demographic, menstrual, and hormonal parameters were comparable between women with and without endometriosis, except obesity – endometriosis being more common in non-obese compared to obese women (27.1% vs. 6.4%, p-value=0.012). Conclusions: Endometriosis was detected in nearly one-sixth of infertile women undergoing diagnostic laparoscopy, supporting its clinically relevant prevalence.

References

Nik Hazlina NH, Norhayati MN, Shaiful Bahari I, Nik Muhammad Arif NA. Worldwide Prevalence, Risk Factors and Psychological Impact of Infertility among Women: A Systematic Review and Meta-Analysis. British Medical Journal Open. 2022 Mar; 12(3): e057132. doi: 10.1136/bmjopen-2021-057132. DOI: https://doi.org/10.1136/bmjopen-2021-057132

Skakkebæk NE, Lindahl-Jacobsen R, Levine H, Andersson AM, Jørgensen N, Main KM et al. Environmental Factors in Declining Human Fertility. Nature Reviews Endocrinology. 2022 Mar; 18(3): 139-57. doi: 10.1038/s41574-021-00598-8. DOI: https://doi.org/10.1038/s41574-021-00598-8

Zuo Y, Jiang TT, Teng Y, Han Y, Yin YP, Chen XS. Associations of Chlamydia Trachomatis Serology with Fertility-Related and Pregnancy Adverse Outcomes in Women: A Systematic Review and Meta-Analysis of Observational Studies. EBioMedicine. 2023 Aug; 94. doi: 10.1016/j.ebiom.2023.104696. DOI: https://doi.org/10.1016/j.ebiom.2023.104696

World Health Organization. Infertility Prevalence Estimates, 1990–2021. World Health Organization. 2023 Apr.

Huang B, Wang Z, Kong Y, Jin M, Ma L. Global, Regional and National Burden of Male Infertility in 204 Countries and Territories Between 1990 and 2019: An Analysis of Global Burden of Disease Study. BioMed Central Public Health. 2023 Nov; 23(1): 2195. doi: 10.1186/s12889-023-16793-3. DOI: https://doi.org/10.1186/s12889-023-16793-3

Munro MG, Balen AH, Cho S, Critchley HO, Díaz I, Ferriani R et al. The FIGO Ovulatory Disorders Classification System. Human Reproduction. 2022 Oct; 37(10): 2446-64.

Signorile PG, Cassano M, Viceconte R, Marcattilj V, Baldi A. Endometriosis: A Retrospective Analysis of Clinical Data from a Cohort of 4,083 Patients, with Focus on Symptoms. In Vivo. 2022 Mar; 36(2): 874-83. doi: 10.21873/invivo.12776. DOI: https://doi.org/10.21873/invivo.12776

Adamczyk M, Wender-Ozegowska E, Kedzia M. Epigenetic Factors in Eutopic Endometrium in Women with Endometriosis and Infertility. International Journal of Molecular Sciences. 2022 Mar; 23(7): 3804. doi: 10.3390/ijms23073804. DOI: https://doi.org/10.3390/ijms23073804

Parazzini F, Roncella E, Cipriani S, Trojano G, Barbera V, Herranz B et al. The Frequency of Endometriosis in the General and Selected Populations: A Systematic Review. Journal of Endometriosis and Pelvic Pain Disorders. 2020 Sep; 12(3-4): 176-89. doi: 10.1177/2284026520933141. DOI: https://doi.org/10.1177/2284026520933141

Martire FG, Piccione E, Exacoustos C, Zupi E. Endometriosis and Adolescence: The Impact of Dysmenorrhea. Journal of Clinical Medicine. 2023 Aug; 12(17): 5624. doi: 10.3390/jcm12175624. DOI: https://doi.org/10.3390/jcm12175624

Maggiore UL, Chiappa V, Ceccaroni M, Roviglione G, Savelli L, Ferrero S et al. Epidemiology of Infertility in Women with Endometriosis. Best Practice and Research Clinical Obstetrics and Gynaecology. 2024 Feb; 92: 102454. doi: 10.1016/j.bpobgyn.2023.102454. DOI: https://doi.org/10.1016/j.bpobgyn.2023.102454

Rao SI, Siddiq S, Sarfraz Z, Rana M. Endometriosis;: Prevalence of Endometriosis on Laparoscopy in Subfertile Women. The Professional Medical Journal. 2019 May; 26(05): 702-6. doi: 10.29309/TPMJ/2019.26.05.2806. DOI: https://doi.org/10.29309/TPMJ/2019.26.05.2806

Nezhat C, Khoyloo F, Tsuei A, Armani E, Page B, Rduch T et al. The Prevalence of Endometriosis in Patients with Unexplained Infertility. Journal of Clinical Medicine. 2024 Jan; 13(2): 444. doi: 10.3390/jcm13020444. DOI: https://doi.org/10.3390/jcm13020444

Abdulrazzaq A. Prevalence of Endometriosis: A Review of Literature Data. Asian Research Journal of Gynaecology and Obstetrics. 2024 Sep; 7(1): 256-63. doi: 10.9734/arjgo/2024/v7i1233. DOI: https://doi.org/10.9734/arjgo/2024/v7i1233

Van Gestel H, Bafort C, Meuleman C, Tomassetti C, Vanhie A. The Prevalence of Endometriosis in Unexplained Infertility: A Systematic Review. Reproductive Biomedicine Online. 2024 Sep; 49(3): 103848. doi: 10.1016/j.rbmo.2024.103848. DOI: https://doi.org/10.1016/j.rbmo.2024.103848

Al-Jafari M, Aldarawsheh MA, Abouzid M, Serag I, Nofal MA, Altiti AR et al. Prevalence of Endometriosis in Women Undergoing Laparoscopic Surgery for Various Gynecological Indications: A Jordanian Multi-Center Retrospective Study. BioMed Central Women's Health. 2024 Dec; 24(1): 669. doi: 10.1186/s12905-024-03527-9. DOI: https://doi.org/10.1186/s12905-024-03527-9

Colombi I, Ginetti A, Cannoni A, Cimino G, d’Abate C, Schettini G et al. Combine Surgery and in Vitro Fertilization (IVF) in Endometriosis-Related Infertility: When and Why. Journal of Clinical Medicine. 2024 Dec; 13(23): 7349. doi: 10.3390/jcm13237349. DOI: https://doi.org/10.3390/jcm13237349

Vannuccini S, Clemenza S, Rossi M, Petraglia F. Hormonal Treatments for Endometriosis: The Endocrine Background. Reviews in Endocrine and Metabolic Disorders. 2022 Jun; 23(3): 333-55. doi: 10.1007/s11154-021-09666-w. DOI: https://doi.org/10.1007/s11154-021-09666-w

Al Shukri M, Al Ghafri W, Gowri V. Are There Predictors of Early Diagnosis of Endometriosis Based on Clinical Profile? A Retrospective Study. Oman Medical Journal. 2023 Jan; 38(1): e458. doi: 10.5001/omj.2023.35. DOI: https://doi.org/10.5001/omj.2023.35

Feferkorn I, Suarthana E, Kigloo HN, Abow‐Mohamed I, Golyari Y, Tulandi T. Combined Effects of Age and Endometriosis on Ovarian Reserve in Women with Infertility. International Journal of Gynecology and Obstetrics. 2023 Apr; 161(1): 129-36. doi: 10.1002/ijgo.14519. DOI: https://doi.org/10.1002/ijgo.14519

Downloads

Published

2026-10-31
Check for updates
CITATION
DOI: 10.54393/pjhs.v7i10.4023
Published: 2026-10-31

How to Cite

Gull, B., Noor, L., Majeed, S., Mumtaz, S., & Naheed, N. (2026). Prevalence of Endometriosis in Women Presenting with Infertility: Hospital-based Cross-sectional Study: Prevalence of Endometriosis in Women Presenting with Infertility. Pakistan Journal of Health Sciences, 7(10), 03–08. https://doi.org/10.54393/pjhs.v7i10.4023

Issue

Section

Original Article

Plaudit

Most read articles by the same author(s)