Comparison of Dexmedetomidine and Labetalol for Attenuating Stress Response in Hypertensive Patients: Dexmedetomidine and Labetalol for Attenuating Stress Response in Hypertensive Patients

Rootaba Khalid; Farrukh Afzal; Shaheer Nayyar; Sumayya Tariq; Shumaila Ashfaq; Sara Sabir; Rehana Feroze

doi:10.54393/pjhs.v7i2.3566

Authors

Rootaba Khalid Department of Anesthesia, Lady Willingdon Hospital, Lahore, Pakistan
Farrukh Afzal Department of Anesthesia, King Edward Medical University, Mayo Hospital, Lahore, Pakistan
Shaheer Nayyar Department of Anesthesia, Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan
Sumayya Tariq Department of Anesthesia, Sharif Medical City Hospital, Lahore, Pakistan
Shumaila Ashfaq Department of Anesthesia, Islam Medical and Dental College, Sialkot, Pakistan
Sara Sabir Department of Anesthesia, Islam Medical and Dental College, Sialkot, Pakistan
Rehana Feroze Department of Anesthesia, Kanad Hospital, Al Ain, United Arab Emirates

DOI:

https://doi.org/10.54393/pjhs.v7i2.3566

Keywords:

Dexmedetomidine, Labetalol, Laryngoscopy, Intubation, Intratracheal, Hemodynamics, Hypertension, General Anesthesia

Abstract

Laryngoscopy and tracheal intubation during general anesthesia provoke a sympathetic stress reaction that has significant hemodynamic changes. This can be risky, particularly in patients with controlled hypertension with compromised cardiovascular reserve. Objective: To compare the effect of dexmedetomidine and labetalol for attenuating stress response in hypertensive patients. Methods: A quasi-experimental study that involved 200 controlled hypertensive patients admitted to the elective surgery and placed under general anesthetic procedures. Patients received Intravenous dexmedetomidine (0.1 mcg/kg) or labetalol (0.1 mg/kg). It was observed that the mean heart rate and mean arterial blood pressure were measured at baseline and two minutes after endotracheal intubation. The statistics were performed using the independent sample t-test, which was used to compare the results observed between the two treatment groups. Results: The heart rate 2 minutes following intubation was much lower in Group D (78 ± 8.27 beats/minute) than in Group L (81 ± 5.30 beats/minute, p=0.0026). Further, the mean arterial blood pressure was declining remarkably in the dexmedetomidine group (98 ± 7.26 mmHg), compared to the labetalol group (101 ± 8.2 mmHg; p=0.0067). Conclusions: The present group of controlled hypertensive patients indicated that dexmedetomidine pre-induction, in comparison to labetalol, led to a significantly more significant reduction of hypertensive and tachycardic reaction to laryngoscopy and endotracheal intubation.

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