Wound Closure Techniques: Subcuticular Vs Interrupted Transdermal Sutures in Paediatric Patients Undergoing Open Appendectomy for Complicated Appendicitis: A Randomized Controlled Trial

Wound Closure Techniques: Subcuticular vs Transdermal Sutures in Children

Authors

  • Muhammad Rehman Waheed Department of Paediatric Surgery, King Edward Medical College, Mayo Hospital, Lahore, Pakistan
  • Batool Fatima Department of Paediatric Surgery, Mayo Hospital, Lahore, Pakistan
  • Syed Salman Hussain Zaidi Department of Paediatric Surgery, Mayo Hospital, Lahore, Pakistan
  • Zuha Zafar Department of Paediatric Surgery, Mayo Hospital, Lahore, Pakistan
  • Babar Shahzad Department of Paediatric Surgery, Mayo Hospital, Lahore, Pakistan
  • Zahra Auqil Department of Paediatric Surgery, Mayo Hospital, Lahore, Pakistan
  • Muhammad Kashif Bashir Department of Paediatric Surgery, Mayo Hospital, Lahore, Pakistan
  • Muhammad Azam Department of Paediatric Surgery, Mayo Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v7i1.3499

Keywords:

Complicated Appendicitis, Interrupted Transdermal, Continuous Subcuticular, Surgical Site Infections, Scar

Abstract

Paediatric patients who undergo open appendectomy for complicated appendicitis face risks of surgical site infections (SSIs) and poor wound healing. Objectives: To compare continuous subcuticular versus interrupted transdermal sutures to determine their effects on SSI rates, scar cosmesis, and overall wound healing. Methods: A randomized controlled trial (TCTR20250527004) was conducted from September 2024 to March 2025, enrolling patients aged ≤12 with complicated appendicitis. Patients of both genders aged up to 12 years presenting to the paediatric surgery emergency with acute appendicitis grade 2 and above. Patients were randomized equally into two groups: Group A (continuous subcuticular closure) and Group B (interrupted transdermal closure). Primary outcomes were SSI, wound dehiscence, and Manchester Scar Scores up to 30 days post-op. Statistical analysis was done using SPSS version 23.0, with t-tests and logistic regression. Results: A total of 112 patients were included in the study, with 56 in each group. The mean number of patients with surgical site infection (SSI) in group A was 1.30 ± 0.46, and in group B mean SSI was 1.37 ± 0.49, with a p value of 0.43.  However, the grade of appendicitis was a significant predictor of infection, with higher grades correlating with increased odds of infection (OR=1.83, p<0.001). The Manchester scar score showed that Group A had a mean of around 15.5+3.24 versus Group B mean of about 17.8 ± 2.92, p-value <0.005. Conclusions: The current study concludes that while both continuous subcuticular and interrupted transdermal suturing led to similar SSI rates.

References

Sharma A, Rajalingam V, Nageswaran H, Best L. A Meta-Analysis on Continuous Versus Interrupted Skin Closure Following Appendicectomy. British Journal of Surgery. 2021 Aug;108(8): 898-907. doi: 10.1093/bjs/znab251. DOI: https://doi.org/10.1093/bjs/znab251

Danwang C, Bigna JJ, Tochie JN, Mbonda A, Mbanga CM, Nzalie RN et al. Global Incidence of Surgical Site Infection After Appendectomy: A Systematic Review and Meta-Analysis. British Medical Journal Open. 2020 Feb; 10(2): 1-7. doi: 10.1136/bmjopen-2019-034266. DOI: https://doi.org/10.1136/bmjopen-2019-034266

Javadi SM, Kasraianfard A, Ghaderzadeh P, Khorshidi HR, Moein A, Makarchian HR et al. Comparison of Subcuticular and Interrupted Suturing Methods for Skin Closure After Appendectomy: A Randomized Controlled Trial. Iranian Red Crescent Medical Journal. 2018 Jan; 20(1): 1-5. doi: 10.5812/ircmj.14469. DOI: https://doi.org/10.5812/ircmj.14469

Scheijmans JC, Haijanen J, Flum DR, Bom WJ, Davidson GH, Vons C et al. Antibiotic Treatment Versus Appendicectomy for Acute Appendicitis in Adults: An Individual Patient Data Meta-Analysis. The Lancet Gastroenterology and Hepatology. 2025 Mar; 10(3): 222-33. doi: 10.1016/S2468-1253(24)00349-2. DOI: https://doi.org/10.1016/S2468-1253(24)00349-2

St Peter SD, Noel-MacDonnell JR, Hall NJ, Eaton S, Suominen JS, Wester T et al. Appendectomy Versus Antibiotics for Acute Uncomplicated Appendicitis in Children: An International, Multicenter, Open-Label, Non-Inferiority, Randomized Trial. The Lancet. 2025 Jan; 405(10474): 233-40. doi: 10.1016/S0140-6736(24)02420-6. DOI: https://doi.org/10.1016/S0140-6736(24)02420-6

Santos LC, Gao J, Filho RCF, Mejia PF, Robinson LB, Camargo CA Jr. National Trends in Hospitalizations for Appendectomy in Children, 2001-2017. Turk J Anaesthesiol Reanim. 2025 May; 53(3): 122-131. doi: 10.4274/TJAR.2025.241755. DOI: https://doi.org/10.4274/TJAR.2025.241755

Azmeraw M, Temesgen D, Kitaw TA, Feleke SF, Haile RN, Kassaw A et al. Surgical Site Infection Following Appendectomy in Children. Scientific Reports. 2025 Feb; 15(1): 1-10. doi: 10.1038/s41598-024-79939-2. DOI: https://doi.org/10.1038/s41598-024-79939-2

Sahoo DR, Naik D, Prasad V, Sunil J. Effect of Peritoneal Non-Closure and Closure During Open Appendectomy on Post-Operative Pain: A Randomized, Double-Blinded Study. Langenbeck's Archives of Surgery. 2025 Dec; 410(1): 1-7. doi: 10.1007/s00423-025-03806-5.

Wang X and Ji X. Sample Size Estimation in Clinical Research: From Randomized Controlled Trials to Observational Studies. Chest. 2020 Jul; 158(1): 12-20. doi: 10.1016/j.chest.2020.03.010. DOI: https://doi.org/10.1016/j.chest.2020.03.010

Verberk JD, van Rooden SM, Hetem DJ, Wunderink HF, Vlek AL, Meijer C et al. Reliability and Validity of Multicentre Surveillance of Surgical Site Infections After Colorectal Surgery. Antimicrobial Resistance & Infection Control. 2022 Jan; 11(1): 1-9. doi: 10.1186/s13756-022-01050-w. DOI: https://doi.org/10.1186/s13756-022-01050-w

Goto S, Sakamoto T, Ganeko R, Hida K, Furukawa TA, Sakai Y. Subcuticular Sutures for Skin Closure in Non‐Obstetric Surgery. Cochrane Database of Systematic Reviews. 2020 April. doi: 10.1002/14651858.CD012124.pub2. DOI: https://doi.org/10.1002/14651858.CD012124.pub2

Luo HM, Hu S, Zhou GY, Bai HY, Lv Y, Wang HB et al. The Effects of Ulinastatin on Systemic Inflammation, Visceral Vasopermeability, and Tissue Water Content in Rats with Scald Injury. Burns. 2013 Aug; 39(5): 916-22. doi: 10.1016/j.burns.2012.11.004. DOI: https://doi.org/10.1016/j.burns.2012.11.004

Bruce MP, Surekha A, Karnaboopathy R, Balan KS, Chavada VK, Boratne AV et al. Assessment of the Reliability and Validity of the Visual Analog Scale for Abdominal Pain Among Selected School Students from Selected Schools at Kanyakumari District. Journal of Family Medicine and Primary Care. 2025 Apr; 14(4): 1179-84. doi: 10.4103/jfmpc.jfmpc_1038_24. DOI: https://doi.org/10.4103/jfmpc.jfmpc_1038_24

Mori M, Shuto K, Kosugi C, Narushima K, Hirano A, Usui A et al. Development and Validation of a New Scoring System to Discriminate Between Uncomplicated and Complicated Appendicitis. Scientific Reports. 2024 Aug; 14(1): 1-8. doi: 10.1038/s41598-024-70904-7. DOI: https://doi.org/10.1038/s41598-024-70904-7

Nasir M, Siddique M, Zaeem A, Raza A, Rizwan M, Abbas M. Comparison of Continuous Versus Simple Interrupted Polypropylene Suture Closure of Midline Emergency Laparotomy Wound in Terms of Wound Outcome in Adult Patients Presenting with Acute Abdomen: Continuous Vs Interrupted Polypropylene Suture Closure of Laparotomy Wound. Pakistan Journal of Health Sciences. 2025 Jan; 6(1): 283-8. doi: 10.54393/pjhs. v6i1.2634. DOI: https://doi.org/10.54393/pjhs.v6i1.2634

Holcomb GW, Murphy JD, Ostlie DJ. Ashcraft’s Pediatric Surgery, 6th Ed. The Annals of the Royal College of Surgeons of England. 2019 Nov; 101(8): 621. doi: 10.1308/003588415X14181254788962. DOI: https://doi.org/10.1308/003588415X14181254788962

Jin J, ′ Akau′ ola S, Yip CH, Nthumba P, Ameh EA, de Jonge S et al. The Impact of Quality Improvement Interventions in Improving Surgical Infections and Mortality in Low and Middle-Income Countries: A Systematic Review and Meta-Analysis. World Journal of Surgery. 2021 Oct; 45(10): 2993-3006. doi: 10.1007/s00268-021-06208-y. DOI: https://doi.org/10.1007/s00268-021-06208-y

Sahoo DR, Naik D, Prasad V, Sunil J. Effect of Peritoneal Non-Closure and Closure During Open Appendectomy on Post-Operative Pain: A Randomized, Double-Blinded Study. Langenbeck's Archives of Surgery. 2025 Dec; 410(1): 1-7. doi: 10.1007/s00423-025-03806-5. DOI: https://doi.org/10.1007/s00423-025-03806-5

Gil LA, Asti L, Nishimura L, Banks AR, Woodard J, Islam S et al. Assessing Alternative Approaches for Wound Closure in A National Pediatric Learning Health System. Journal Of Surgical Research. 2024 Mar; 295: 783-90. doi: 10.1016/j.jss.2023.11.068. DOI: https://doi.org/10.1016/j.jss.2023.11.068

Garzon-González LN, Padilla LT, Patiño F, Hernández MA, Valero J, Molina ID et al. Association Between Bacterial Resistance Profile and the Development of Intra-Abdominal Abscesses in Pediatric Patients with Perforated Appendicitis: Cohort Study. Pediatric Surgery International. 2023 Dec; 40(1): 1-9. doi: 10.1007/s00383-023-05570-3. DOI: https://doi.org/10.1007/s00383-023-05570-3

Downloads

Published

2026-01-31
CITATION
DOI: 10.54393/pjhs.v7i1.3499
Published: 2026-01-31

How to Cite

Waheed, M. R., Fatima, B., Zaidi, S. S. H., Zafar, Z., Shahzad, B., Auqil, Z., Bashir, M. K., & Azam, M. (2026). Wound Closure Techniques: Subcuticular Vs Interrupted Transdermal Sutures in Paediatric Patients Undergoing Open Appendectomy for Complicated Appendicitis: A Randomized Controlled Trial: Wound Closure Techniques: Subcuticular vs Transdermal Sutures in Children. Pakistan Journal of Health Sciences, 7(1), 20–26. https://doi.org/10.54393/pjhs.v7i1.3499

Issue

Section

Original Article

Plaudit