Hypomagnesemia in Diabetic Patients and Its Correlation with Glycemic Control
Hypomagnesemia and Glycemic Control
DOI:
https://doi.org/10.54393/pjhs.v6i10.3454Keywords:
Hypomagnesemia, Diabetes Mellitus, Glycemic Control, HbA1cAbstract
Diabetes mellitus is a growing pandemic of the modern era with a wide array of complications. Better glycemic control is linked to improved survival and quality of life in diabetes patients. Serum magnesium levels have been postulated to adversely affect glycemic targets. Objectives: To determine hypomagnesemia prevalence in diabetic patients and its correlation with glycemic control. Methods: This cross-sectional observational study was conducted over six months from January 2025 to June 2025 at the diabetic clinical Jinnah Hospital, Lahore. A total of 174 patients fulfilling the inclusion criteria were enrolled in the study following a non-probability consecutive sampling technique. Informed consent was obtained from the participant. Data were recorded on a predesigned proforma, and analysis was run using SPSS version 25.0 version. Results: Out of the total 174 patients, 51 patients had normal magnesium levels, and 123 patients were hypomagnesemic. Poor glycemic control (HbA1C>7.0%) was significantly more prevalent (p=0.001) in hypomagnesemic patients. Although most of the female patients were having low serum magnesium levels (n=77), this gender difference was non-significant (p-value=0.450). Age-wise distribution of hypomagnesemia showed significantly more predilection (p=0.001) for 45 to 60 years age patients. Conclusions: The study concluded that hypomagnesemia is significantly linked to poor glycemic control in diabetic patients. Further studies are needed to explore the relationship between serum magnesium and dysglycemia.
References
Yameny AA. Diabetes Mellitus Overview 2024. Journal of Bioscience and Applied Research. 2024 Sep; 10(3): 641-5. doi: 10.21608/jbaar.2024.382794 DOI: https://doi.org/10.21608/jbaar.2024.382794
Hossain MJ, Al-Mamun M, Islam MR. Diabetes Mellitus, the Fastest Growing Global Public Health Concern: Early Detection Should Be Focused. Health Science Reports. 2024 Mar; 7(3): e2004. doi: 10.1002/hsr2.2004. DOI: https://doi.org/10.1002/hsr2.2004
Azeem S, Khan U, Liaquat A. The Increasing Rate of Diabetes in Pakistan: A Silent Killer. Annals of Medicine and Surgery. 2022 Jul; 79: 103901. doi: 10.1016/j.amsu.2022.103901. DOI: https://doi.org/10.1016/j.amsu.2022.103901
Hasan SU, Siddiqui MR. Epidemiology of Diabetes Mellitus in Pakistan: A Systematic Review Protocol. BMJ Open. 2024 Mar; 14(3): e079513. doi: 10.1136/bmjopen-2023-079513. DOI: https://doi.org/10.1136/bmjopen-2023-079513
Lee SH, Park SY, Choi CS. Insulin Resistance: From Mechanisms to Therapeutic Strategies. Diabetes and Metabolism Journal. 2022 Jan; 46(1): 15-37. doi: 10.4093/dmj.2021.0280. DOI: https://doi.org/10.4093/dmj.2021.0280
Chutia H, Lynrah KG. Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus. Journal of Laboratory Physicians. 2015 Jul; 7(2): 75-8. doi: 10.4103/0974-2727.163131. DOI: https://doi.org/10.4103/0974-2727.163131
Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in Type 2 Diabetes Mellitus. Indian Journal of Endocrinology and Metabolism. 2012 Nov; 16(6): 1000-3. doi: 10.4103/2230-8210.103020. DOI: https://doi.org/10.4103/2230-8210.103020
Pham PC, Pham PM, Pham SV, Miller JM, Pham PT. Hypomagnesemia in Patients with Type 2 Diabetes. Clinical Journal of the American Society of Nephrology. 2007 Mar; 2(2): 366-73. doi: 10.2215/CJN.02960906. DOI: https://doi.org/10.2215/CJN.02960906
Eker ES, Ataoğlu HE. The Relationship between Hypomagnesemia and Albuminuria in Patients with Type 2 Diabetes Mellitus. Clinical Endocrinology. 2024 Sep; 101(3): 216-22. doi: 10.1111/cen.15094. DOI: https://doi.org/10.1111/cen.15094
Kazmi SK, Farooq M, Iftikhar I, Fatima N, Shahzad M, Ijaz AU, Khalid H, et al. Association of Hypomagnesemia with Diabetic Complications. Cureus. 2024 Mar; 16(3). doi: 10.7759/cureus.56605. DOI: https://doi.org/10.7759/cureus.56605
Ahmed F, Mohammed A. Magnesium: the Forgotten Electrolyte – A Review on Hypomagnesemia. Medical Sciences. 2019 Apr; 7(4): 56. doi: 10.3390/medsci7040056. DOI: https://doi.org/10.3390/medsci7040056
Hansen BA, Bruserud Ø. Hypomagnesemia in Critically Ill Patients. Journal of Intensive Care. 2018 Mar; 6(1): 21. doi: 10.1186/s40560-018-0291-y. DOI: https://doi.org/10.1186/s40560-018-0291-y
Oost LJ, Tack CJ, de Baaij JH. Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes. Endocrine Reviews. 2023 Jun; 44(3): 357-78. doi: 10.1210/endrev/bnac028. DOI: https://doi.org/10.1210/endrev/bnac028
Pitliya A, Vasudevan SS, Batra V, Patel MB, Desai A, Nethagani S, Pitliya A, et al. Global Prevalence of Hypomagnesemia in Type 2 Diabetes Mellitus – A Comprehensive Systematic Review and Meta-Analysis of Observational Studies. Endocrine. 2024 Jun; 84(3): 842-51. doi: 10.1007/s12020-023-03670-7. DOI: https://doi.org/10.1007/s12020-023-03670-7
Hamarshih M, Hamshari S, Nazzal Z, Snobar F, Mletat R, Abu-Mazen O, Maraqa B, et al. Hypomagnesemia and Poor Glycemic Control among Type 2 Diabetic Patients: A Cross-Sectional Study. Indian Journal of Endocrinology and Metabolism. 2022 Nov; 26(6): 575-80. doi: 10.4103/ijem.ijem_213_22. DOI: https://doi.org/10.4103/ijem.ijem_213_22
Odusan OO, Familoni OB, Odewabi AO, Idowu AO, Adekolade AS. Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria. Indian Journal of Endocrinology and Metabolism. 2017 May; 21(3): 439-42. doi: 10.4103/ijem.IJEM_190_16. DOI: https://doi.org/10.4103/ijem.IJEM_190_16
Morais JB, Severo JS, de Alencar GR, de Oliveira AR, Cruz KJ, do Nascimento Marreiro D, de Carvalho CM, et al. Effect of Magnesium Supplementation on Insulin Resistance in Humans: A Systematic Review. Nutrition. 2017 Jun; 38: 54-60. doi: 10.1016/j.nut.2017.01.009. DOI: https://doi.org/10.1016/j.nut.2017.01.009
Al-Daghri NM, Yakout SM, Hussain SD, Alnaami AM, Veronese N, Barbagallo M, Sabico S, et al. Hypomagnesemia in Adults with Type 2 Diabetes Mellitus in Riyadh, Saudi Arabia: A Cross-Sectional Study. Medicine. 2025 Jan; 104(3): e41253. doi: 10.1097/MD.0000000000041253. DOI: https://doi.org/10.1097/MD.0000000000041253
Sadeghian M, Azadbakht L, Khalili N, Mortazavi M, Esmaillzadeh A. Oral Magnesium Supplementation Improved Lipid Profile but Increased Insulin Resistance in Patients with Diabetic Nephropathy: A Double-Blind Randomized Controlled Clinical Trial. Biological Trace Element Research. 2020 Jan; 193(1): 23-35. doi: 10.1007/s12011-019-01687-6. DOI: https://doi.org/10.1007/s12011-019-01687-6
Bherwani S, Jibhkate SB, Saumya AS, Patel SK, Singh R, Ghotekar LH. Hypomagnesemia: A Modifiable Risk Factor of Diabetic Nephropathy. Hormone Molecular Biology and Clinical Investigation. 2017 Mar; 29(3): 79-84. doi: 10.1515/hmbci-2016-0024. DOI: https://doi.org/10.1515/hmbci-2016-0024
Shivakumar K, Rajalakshmi AR, Jha KN, Nagarajan S, Srinivasan AR, Lokesh Maran A. Serum Magnesium in Diabetic Retinopathy: The Association Needs Investigation. Therapeutic Advances in Ophthalmology. 2021 Dec; 13: 25158414211056385. doi: 10.1177/25158414211056385. DOI: https://doi.org/10.1177/25158414211056385
Abubaker S, Albasseet A, El-Abd KA, Alandijani AA, Alendijani YA, Alkhenizan A, Elabd K, et al. Association between Vitamin D Levels and Glycemic Control among Adult Diabetic Patients in Riyadh, Saudi Arabia. Cureus. 2022 Jun; 14(6). doi: 10.7759/cureus.25919. DOI: https://doi.org/10.7759/cureus.25919
Safarzad M, Jazi MS, Kiaei M, Asadi J. Lower Serum Zinc Level is Associated with Higher Fasting Insulin in Type 2 Diabetes Mellitus (T2DM) and Relates with Disturbed Glucagon Suppression Response in Male Patients. Primary Care Diabetes. 2023 Oct; 17(5): 493-8. doi: 10.1016/j.pcd.2023.05.008. DOI: https://doi.org/10.1016/j.pcd.2023.05.008
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