Impact of Endoscopic Thoracic Sympathectomy among Hyperhidrosis Patients at A Tertiary Care Center
Endoscopic Thoracic Sympathectomy among Hyperhidrosis Patients
DOI:
https://doi.org/10.54393/pjhs.v6i6.3206Keywords:
Hyperhidrosis, Endoscopic Thoracic Sympathectomy, Sweating, MenopauseAbstract
Hyperhidrosis is characteristically termed as excessive sweating excessively even during normal situations. Objectives: To assess the dynamics of sweating in patients with hyperhidrosis before and after treatment with Endoscopic Sympathectomy (ETS). Methods: This pre-post intervention research was carried out at the Thoracic Surgery Unit of Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Patients presenting with sweating of either gender, between 18 to 60 years of age, diagnosed with primary hyperhidrosis, were included in the study. Patients having secondary hyperhidrosis, female with symptoms of menopause, patients having generalized sweating, with severe or multiple co-morbidities such as pulmonary or cardiac issues, chronic illness (uncontrolled) or with any neurological condition were excluded from the study. SPSS version 23.0 was used for data analysis. Paired Student t-test was applied for sweating parameters before and after ETS, keeping p<0.05 statistically significant. Results: The study included 53 patients with a mean age of (34.55 ± 8.72) years, nearly equally distributed by gender. Axillary hyperhidrosis was the most common type (43.4%), and most patients had HDSS grades 3or 4. Post-ETS, all sweat parameters showed significant improvement. Notably, BSR reduced to 0.09 ± 0.07 mg/min/cm², PSR to 0.2 ± 0.17 mg/min/cm², SV to 0.07 ± 0.05 mg/cm², and ST to (12.28 ± 10.8) seconds. These findings demonstrate that ETS effectively reduces the severity and extent of sweating in patients with hyperhidrosis. Conclusions: A significant reduction in sweating parameters of patients with hyperhidrosis undergoing Endoscopic Thoracic Sympathectomy.
References
Parashar K, Adlam T, Potts G. The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature. American Journal of Clinical Dermatology. 2023 Mar; 24(2): 187-98. doi: 10.1007/s40257-022-00743-7.
Wadhawa S, Agrawal S, Chaudhary M, Sharma S. Hyperhidrosis Prevalence: A Disease Underreported by Patients and Underdiagnosed by Physicians. Indian Dermatology Online Journal. 2019 Nov; 10(6): 676-81. doi: 10.4103/idoj.IDOJ_55_19.
D Cataneo AJ. Hyperhidrosis: Prevalence and Impact on Quality of Life. Jornal Brasileiro de Pneumologia. 2018; 44(4). doi: 10.1590/s1806-37562017000000379.
Hasimoto EN, Cataneo DC, Dos Reis TA, Cataneo AJ. Hyperhidrosis Prevalence and Its Impact on Population. Shanghai Chest. 2019 Jun; 3. doi: 10.21037/shc.2019.05.05.
Henning MA, Bouazzi D, Jemec GB. Treatment of Hyperhidrosis: An Update. American Journal of Clinical Dermatology. 2022 Sep; 23(5): 635-46. doi: 10.1007/s40257-022-00707-x.
Ho YL, Fauzi M, Sothee K, Basheer A. Diagnosis, Impact and Management of Hyperhidrosis Including Endoscopic Thoracic Sympathectomy. Medical Journal of Malaysia. 2020 Sep; 75(5): 555-60.
Katrancıoğlu Ö, Karadayı Ş, Karabacak M. Sympathectomy in the Treatment of Hyperhidrosis: Is It an Effective Solution? Journal of Medical Topics and Updates. 2024; 3(1): 9-13. doi: 10.58651/jomtu.1421646.
Leung BW, Collier MR, Tiu BC, Wan G, Nguyen N, Tang K et al. Patterns in Utilization of Health Care Services and Medications Among Patients with Cutaneous Immune-Related Adverse Events: A Population-Level Cohort Study. Journal of the American Academy of Dermatology. 2023 May; 88(5): 1215-8. doi: 10.1016/j.jaad.2022.12.042.
Lin ZY and Lin M. Which Patients Are More Likely to Experience Compensatory Hyperhidrosis After Endoscopic Thoracic Sympathectomy: A Meta-Analysis and Systematic Review. Peerj. 2025 Mar; 13: E19097. doi: 10.7717/peerj.19097.
Du X, Zhu X, Wang T, Hu X, Lin P, Teng Y et al. Compensatory Hyperhidrosis After Different Surgeries at the Same Sympathetic Levels: A Meta-Analysis. Annals of Translational Medicine. 2018 Jun; 6(11): 203. doi: 10.21037/atm.2018.05.24.
Polaczek M, Szaro P, Jakubowska L, Zych J, Religioni J, Orlowski TM. Pulmonary Veins Variations with Potential Impact in Thoracic Surgery: A Computed-Tomography-Based Atlas. Journal of Thoracic Disease. 2020 Mar; 12(3): 383. doi: 10.21037/jtd.2020.01.34.
Borghese O, Pisani A, Mastracci TM. Challenges in Diagnosis of Non-a Non-b Acute Aortic Dissection. Annals of Vascular Surgery. 2024 Nov; 108: 212-8. doi: 10.1016/j.avsg.2024.05.010.
Wang J, Zhao S, Tang B, Xiang M, Dai J, Liu Q. Quality of Life and Compensatory Hyperhidrosis Following Thoracoscopic Sympathectomy: A Retrospective Cohort Study. Journal of Cardiothoracic Surgery. 2025 Dec; 20(1): 1-7. doi: 10.1186/s13019-025-03393-y.
Wohlrab J, Bechara FG, Schick C, Naumann M. Hyperhidrosis: A Central Nervous Dysfunction of Sweat Secretion. Dermatology and Therapy. 2023 Feb; 13(2): 453-63. doi: 10.1007/s13555-022-00885-w.
Behinaein P, Gavagan K, Waitzman J, Pourang A, Potts G. A Review of the Etiologies and Key Clinical Features of Secondary Hyperhidrosis. American Journal of Clinical Dermatology. 2025 Jan; 26(1): 97-108. doi: 10.1007/s40257-024-00908-6.
Stuart ME, Strite SA, Gillard KK. A Systematic Evidence-Based Review of Treatments for Primary Hyperhidrosis. Journal of Drug Assessment. 2021 Dec; 10(1): 35-50. doi: 10.1080/21556660.2020.1857149.
Wong NS, Adlam TM, Potts GA, Farshchian M. Hyperhidrosis: A Review of Recent Advances in Treatment with Topical Anticholinergics. Dermatology and Therapy. 2022 Dec; 12(12): 2705-14. 10.1007/s13555-022-00838-3.
Woo W, Kim BJ, Kang DY, Won J, Moon DH, Lee S. Patient Experience and Prognostic Factors of Compensatory Hyperhidrosis and Recurrence After Endoscopic Thoracic Sympathicotomy. Surgical Endoscopy. 2022 Nov; 36(11): 8340-8. doi: 10.1007/s00464-022-09284-w.
Ashida M, Koga T, Morimoto S, Yozaki M, Ehara D, Koike Y et al. Evaluation of Sweating Responses in Patients with Collagen Disease Using the Quantitative Sudomotor Axon Reflex Test (QSART): A Study Protocol for an Investigator-Initiated, Prospective, Observational Clinical Study. British Medical Journal Open. 2021 Oct; 11(10): E050690. doi: 10.1136/bmjopen-2021-050690.
Hirakawa N, Higashimoto I, Takamori A, Tsukamoto E, Uemura Y. The Impact of Endoscopic Thoracic Sympathectomy on Sudomotor Function in Patients with Palmar Hyperhidrosis. Clinical Autonomic Research. 2021 Apr; 31(2): 225-30. doi: 10.1007/s10286-020-00685-2.
Mitani Y, Miyaji K, Kaneko S, Uekura T, Momose H, Johguchi K. A Compact Perspiration Meter System with Capacitive Humidity Sensor for Wearable Health-Care Applications. Japanese Journal of Applied Physics. 2018 Mar; 57(4S): 04FF10. 10.7567/JJAP.57.04FF10.
Schote AB, Dietrich K, Linden AE, Dzionsko I, Molano Moreno LD, Winnikes U et al. Real Sweating in A Virtual Stress Environment: Investigation of the Stress Reactivity in People with Primary Focal Hyperhidrosis. PLOS One. 2022 Aug 2; 17(8): e0272247. doi: 10.1371/journal.pone.0272247.
Diehl RL. Constraints Caused by Primary Hyperhidrosis. In Hyperhidrosis: A Complete Guide to Diagnosis and Management. Cham: Springer International Publishing. 2018 Jul: 65-72. doi: 10.1007/978-3-319-89527-7_11.
Henning MA, Barati F, Jemec GB. Quality of Life in Individuals with Primary Hyperhidrosis: A Systematic Review and Meta-Analysis. Clinical Autonomic Research. 2023 Aug; 33(4): 519-28. doi: 10.1007/s10286-023-00954-w.
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