C-Reactive Protein (CRP) and Total Leukocyte Count (TLC) as Inflammatory Markers for Monitoring the Progression of Odontogenic Fascial Space Infection : C-Reactive Protein and Leukocyte Count in Odontogenic Infections

Haseeb Uddin; Rutaba  Ashraf; Benish  Pervaiz; Noor Ul Ain; Muhammad Umar Farooq; Mor Khan Shar

doi:10.54393/pjhs.v6i4.2799

Authors

Haseeb Uddin Department of Oral and Maxillofacial Surgery, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Rutaba Ashraf Department of Oral and Maxillofacial Surgery, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Benish Pervaiz Department of Oral and Maxillofacial Surgery, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Noor Ul Ain Department of Oral and Maxillofacial Surgery, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Muhammad Umar Farooq Department of Oral and Maxillofacial Surgery, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Mor Khan Shar Department of Oral and Maxillofacial Surgery, School Of Dentistry, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i4.2799

Keywords:

Odontogenic Infection, C-Reactive Protein, Total Leukocyte Count, Maxillofacial Space Infection, Postoperative Monitoring

Abstract

Dental infections can cause serious morbidity and mortality even with modern medical improvements. When infections from tooth pulp rupture cortical plate and move via fascial channels, they can spread through bone or periodontal tissues and result in potentially fatal consequences. Objective: To determine frequency of increased levels of C-Reactive Protein (CRP) and Total Leukocyte Count (TLC) and mean change in CRP and TLC during the course of treatment in Odontogenic fascial space infection. Methods: A descriptive cross-sectional study was conducted in OMFS department at PIMS, involving patients with odontogenic infections. Blood samples were taken before and at specified intervals to monitor CRP and TLC levels such as before Incision and Drainage (I&D) and post I&D (after two hours of meal at 1^st , 2nd, 3rd, and 7th d post I&D Day. Using SPSS Version 23.0, frequencies, percentages, means, and standard deviations were measured to examine both quantitative and qualitative data. Results: There were 43 (55%) females and 35 (45%) males with a mean age of 39.17 ± 14.68 years. 17% showed elevated CRP levels and 12% presented with elevated TLC levels after seven days of follow-up. Pearson correlation was significant preoperatively and on 1^st and the 2^ndday Postoperatively as P value was 0.000. Conclusions: This study highlighted importance of monitoring CRP and TLC levels in odontogenic maxillofacial infections, both markers indicate inflammation. CRP is more sensitive than TLC during treatment, making it valuable tool for postoperative assessment.

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