Cytomorphological Spectrum of Breast Fine Needle Aspiration Cytology Using International Academy Cytology Yokohama System- A Retrospective Study in the Tertiary Care Center of Sahiwal
Cytomorphological Spectrum of Breast Fine Needle Aspiration Cytology
DOI:
https://doi.org/10.54393/pjhs.v6i6.2678Keywords:
Breast Cancer, Fine Needle Aspiration Cytology, Benign, Malignant, AtypicalAbstract
Breast carcinoma is also a very widespread and upsetting cancer that pertains to women, and the incidence of the same is also high in developing countries. Breast cancer is one of the most common malignancies women are exposed to, and its occurrence is particularly high in third-world countries. Fine needle aspiration cytology (FNAC) is a good diagnostic tool when it comes to the detection of early breast lesions. Objectives: To evaluate the role of FNAC in the screening and assessment of breast lumps to identify breast cancer in the resource-poor Sahiwal Division. Methods: This retrospective cross-sectional study included 392 females presenting with palpable breast lumps. After obtaining informed consent, FNAC was performed, and the aspirated material was used to prepare and stain slides for cytological examination. The data were collected from clinical records and then analyzed. Results: Out of 392 female patients, the majority of breast lesions (40.05%) were found in C5; malignant category followed by 26.78% in C2(benign), 21.93% of lesions in C3 (atypical), and 10.52% in C4 (suspicious for malignancy) categories. Most of the patients (39.84%) were aged 41 and above, and 143 patients (36.48%) were seen in category 5whereas the duration of lesion according to history of disease for the majority of cases (36.48%) can be seen from 7 to 12 months in reporting category 5 (40.86%). Conclusions: The fine needle aspiration cytology (FNAC) is associated with fast, trustworthy, and economical means of initial classification of palpable breast growths on the basis of the standardized IAC system.
References
Panwar H, Ingle P, Santosh T, Singh V, Bugalia A, Hussain N. FNAC of Breast Lesions with Special Reference to IAC Standardized Reporting and Comparative Study of Cytohistological Grading of Breast Carcinoma. Journal of Cytology. 2020 Jan; 37(1): 34-9. doi: 10.4103/JOC.JOC_132_18.
Rehan M, Qaiser M, Ijaz A. Fine Needle Aspiration Cytology: A Pre-Operative Diagnostic Modality in Breast Lump: A Review of 287 Cases in a Tertiary Care Hospital. Journal of Rawalpindi Medical College. 2019 Feb; 23(S-1): 12-7.
Sharif A, Tabassum T, Riaz M, Akram M, Munir N. Cytomorphological Patterns of Palpable Breast Lesions Diagnosed on Fine Needle Aspiration Cytology in Females. European Journal of Inflammation. 2020 Jul; 18: 2058739220946140. doi: 10.1177/2058739220946140. DOI: https://doi.org/10.1177/2058739220946140
Embaye KS, Raja SM, Gebreyesus MH, Ghebrehiwet MA. Distribution of Breast Lesions Diagnosed by Cytology Examination in Symptomatic Patients at Eritrean National Health Laboratory, Asmara, Eritrea: A Retrospective Study. BMC Women's Health. 2020 Nov; 20(1): 250. doi: 10.1186/s12905-020-01116-0. DOI: https://doi.org/10.1186/s12905-020-01116-0
Zaheer S, Shah N, Maqbool SA, Soomro NM. Estimates of Past and Future Time Trends in Age-Specific Breast Cancer Incidence Among Women in Karachi, Pakistan: 2004-2025. BMC Public Health. 2019 Jul;19(1): 1001. doi: 10.1186/s12889-019-7330-z. DOI: https://doi.org/10.1186/s12889-019-7330-z
Samad A, Fayyaz N, Ali KS, Ashraf A, Mahmood N, Kashif M. Scrutinizing the Patients with Breast Lump on Fine Needle Aspiration Cytology. International Journal of Community Medicine and Public Health. 2019 Feb; 6(2): 1. doi: 10.18203/2394-6040.ijcmph20190061. DOI: https://doi.org/10.18203/2394-6040.ijcmph20190061
Rajani T, Gupta P, Popat VC, Desai NJ. Sensitivity of Ultrasonography in Predicting Benign and Malignant Masses of Breast Lump at a Tertiary Care Hospital with Its Cytological and Histological Correlation. International Journal of Clinical and Diagnostic Pathology. 2020; 3(2): 78-80. doi: 10.33545/pathol.2020.v3.i2b.225. DOI: https://doi.org/10.33545/pathol.2020.v3.i2b.225
Field AS, Schmitt F, Vielh P. IAC Standardized Reporting of Breast Fine-Needle Aspiration Biopsy Cytology. Acta Cytologica. 2017 Feb; 61(1): 3-6. doi: 10.1159/000450880. DOI: https://doi.org/10.1159/000450880
Badge SA, Ovhal AG, Azad K, Meshram AT. Study of Fine-Needle Aspiration Cytology of Breast Lumps in Rural Area of Bastar District, Chhattisgarh. Medical Journal of Dr. DY Patil University. 2017 Jul; 10(4): 339-42. doi: 10.4103/MJDRDYPU.MJDRDYPU_250_16. DOI: https://doi.org/10.4103/MJDRDYPU.MJDRDYPU_250_16
Daramola AO, Odubanjo MO, Obiajulu FJ, Ikeri NZ, Banjo AA. Correlation Between Fine-Needle Aspiration Cytology and Histology for Palpable Breast Masses in a Nigerian Tertiary Health Institution. International Journal of Breast Cancer. 2015; 2015(1): 742573. doi: 10.1155/2015/742573. DOI: https://doi.org/10.1155/2015/742573
Sarfraz T, Bashir S, Arif S, Rehman S, Samad F, Ahmed J. Evaluation of Breast Lumps Through Fine Needle Aspiration Cytology in Urban Area of District Dera Ismail Khan: A Study of 100 Cases. Pakistan Armed Forces Medical Journal. 2021 Apr; 30(2): 490.
Roheen T, Wattoo F, Saleem K, Javed F, Iqbal F, Aslam S. FNAC: A Valuable Tool in Diagnosing Breast Lesions and Its Correlation with Histopathology. Annals of Punjab Medical College. 2022; 16(4): 243-7.
Panwar H, Ingle P, Santosh T, Singh V, Bugalia A, Hussain N. FNAC of Breast Lesions with Special Reference to IAC Standardized Reporting and Comparative Study of Cytohistological Grading of Breast Carcinoma. Journal of Cytology. 2020 Jan; 37(1): 34-9. doi: 10.4103/JOC.JOC_132_18. DOI: https://doi.org/10.4103/JOC.JOC_132_18
Rahman MZ and Islam S. Fine Needle Aspiration Cytology of Palpable Breast Lump: A Study of 1778 Cases. Surgery. 2013; 12: 2161-1076. doi: 10.4172/2161-1076.S12-001. DOI: https://doi.org/10.4172/2161-1076.S12-001
Chandanwale SS, Gupta K, Dharwadkar AA, Pal S, Buch AC, Mishra N. Pattern of Palpable Breast Lesions on Fine Needle Aspiration: A Retrospective Analysis of 902 Cases. Journal of Mid-Life Health. 2014 Oct; 5(4): 186-91. doi: 10.4103/0976-7800.145164. DOI: https://doi.org/10.4103/0976-7800.145164
Shrestha R, Vaidya P, Adhikari M, Adhikari SV, Shrestha A. Role of FNAC in Breast Lump and Its Histopathological Correlation. Journal of Nepalgunj Medical College. 2024 Sep; 22(1): 7-10. doi: 10.3126/jngmc.v22i1.69700. DOI: https://doi.org/10.3126/jngmc.v22i1.69700
Tripathi K, Yadav R, Maurya SK. A Comparative Study Between Fine-Needle Aspiration Cytology and Core Needle Biopsy in Diagnosing Clinically Palpable Breast Lumps. Cureus. 2022 Aug; 14(8). doi: 10.7759/cureus.27709. DOI: https://doi.org/10.7759/cureus.27709
Umat PD, Desai H, Goswami H. Correlation Between BI-RADS Categories and Cytological Findings of Breast Lesions. International Journal of Clinical and Diagnostic Pathology. 2020; 3(3): 43-8. doi: 10.33545/pathol.2020.v3.i3a.259. DOI: https://doi.org/10.33545/pathol.2020.v3.i3a.259
Adeloye D, Sowunmi OY, Jacobs W, David RA, Adeosun AA, Amuta AO, et al. Estimating the Incidence of Breast Cancer in Africa: A Systematic Review and Meta-Analysis. Journal of Global Health. 2018 Apr; 8(1): 010419. doi: 10.7189/jogh.08.010419. DOI: https://doi.org/10.7189/jogh.08.010419
Ogbuanya AU, Anyanwu SN, Nwigwe GC, Iyare FE, Emegoakor CD, Chianakwana GU, et al. Diagnostic Accuracy of Fine Needle Aspiration Cytology for Palpable Breast Lumps in a Nigerian Teaching Hospital. Nigerian Journal of Clinical Practice. 2021 Jan; 24 (1): 69-74. doi: 10.4103/njcp.njcp_540_19. DOI: https://doi.org/10.4103/njcp.njcp_540_19
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Pakistan Journal of Health Sciences

This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open-access journal and all the published articles / items are distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. For comments