Association of C-Reactive Protein and D-dimer Status with Maternal Outcomes in Pregnant Women with COVID-19: C-Reactive Protein and D-dimer Status in Pregnant Women with COVID-19

Summera Aslam; Zeeshan Kashif; Sajida Razzaq; Ushna Laraib; Shamila Ijaz Munir; Shamsa Humayun

doi:10.54393/pjhs.v6i6.2676

Authors

Summera Aslam Department of Gynaecology and Obstetrics, Khawaja Muhammad Safdar Medical College, Allama Iqbal Memorial Teaching Hospital and Allied Institutes, Sialkot, Pakistan
Zeeshan Kashif Department of Anatomy, Combined Military Hospital, Lahore, Pakistan
Sajida Razzaq Department of Gynaecology, District Headquarters Hospital, Narowal, Pakistan
Ushna Laraib Department of Gynaecology, Sir Ganga Ram Hospital, Lahore, Pakistan
Shamila Ijaz Munir Department of Gynaecology, Sir Ganga Ram Hospital, Lahore, Pakistan
Shamsa Humayun Department of Medical Education, College of Physicians and Surgeons Pakistan, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pjhs.v6i6.2676

Keywords:

COVID 19, D Dimers, Maternal Outcomes , C-reactive Protein

Abstract

C-reactive protein (CRP) and D-dimer are crucial biomarkers that play a key role in maternal health, helping to assess risks and minimize complications. Objectives: To find the association of CRP and D-dimer status with maternal outcomes in pregnant women with COVID-19. Methods: The prospective cohort study was carried out at the Department of Obstetrics and Gynaecology, Sir Ganga Ram Hospital, Lahore, from July to September 2020. Demographic data, laboratory parameters including COVID-19, D-dimer and CRP levels and maternal outcomes were recorded. Crosstabs and binary logistic regression analyses were performed to measure the risk of adverse maternal outcomes. Results: Among 112 COVID-19 suspects, 58 (51.8%) were diagnosed as COVID-19 positive, 82 (73.2%) tested positive for CRP, and 19 (17.0%) were D-dimer positive. COVID-19 positive women exhibited twice the mean D-dimer levels (0.92 ± 1.36 vs. 0.43 ± 0.70 µg/mL) and a slightly lower mean CRP level (26.47 ± 31.55 vs. 29.30 ± 32.79 mg/L). Ventilator requirement (32.8% vs. 11.1%) and maternal death rate (29.3% vs. 11.1%) were three times higher in COVID-19 positive cases as compared to the COVID-19 negative cases.CRP positive status and COVID-19 positive showed a statistically significant association and higher risk for ventilator requirement as well as maternal death. However, D-dimer positive status did not show any association with ventilator requirement and maternal death. Conclusions: COVID-19 positivity and CRP positivity in pregnant women are associated with adverse maternal outcomes, including increased ventilator requirement and mortality. However, D-dimer positivity was not related to these adverse maternal outcomes.

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